Mini-pig 하악골에서 저강도진동초음파가 골형성에 미치는 영향
The Effect of Low-intensity Pulsed Ultrasound on Osteogenesis in Mini-pig Mandibles
윤영은, 이준, 민승기, 김상중,
소속 상세정보
윤영은 ( Yun Yeong-Eun ) - 선치과병원 구강악안면외과
이준 ( Lee Jun ) - 원광대학교 치과대학 구강악안면외과학교실
민승기 ( Min Seung-Ki ) - 원광대학교 치과대학 구강악안면외과학교실
김상중 ( Kim Sang-Jung ) - 선치과병원 구강악안면외과
KMID : 0360120110330060467
Abstract
Purpose: The objective of this study was to examine the affected period and the amount of bone formation during osteogenesis of intramembranous bone using low-intensity pulsed ultrasound (LPUS) in vivo.
Methods: Xeno-bone (Bio-oss) and autogenous bone were grafted bilaterally into mini-pig mandibles. The left mandible served as the control and the other mandible was treated with 3 MHz, 160 mW (output, 0.8 mW) ultrasound stimulation for 7 days 15 minutes per day. The mini-pigs were sacrificed at 1, 2, 4, and 8 weeks, and micro computed tomography (microCT), a microscopic examination, and a statistical analysis were performed on the specimens.
Results: Based on a computerized image analysis of the microCT scans, the experimental group had an average 150% more new bone formation than that in the control group. The effect of LPUS continued during the post operative 2 weeks. The histomorphological microscopic examination showed similar results.
Conclusion: Our results suggest the LPUS had an effect on early intramembranous bone formation in vivo.
키워드
Low-intensity pulsed ultrasound; in vivo; Intramembranous bone; μCT
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